Bioadhesive Polymer Semiconductors and Transistors For Intimate Biointerfaces

Authors

Nan Li, University of Chicago
Yang Li, University of Chicago
Zhe Cheng, University of Chicago
Youdi Liu, University of Chicago
Yahao Dai, University of Chicago
Seounghun Kang, University of Chicago
Songsong Li, University of Chicago
Naisong Shan, University of Chicago
Shinya Wai, University of Chicago
Aidan Ziaja, University of Chicago
Yunfei Wang, University of Southern Mississippi
Joseph Strzalka, Argonne National Laboratory
Wei Liu, University of Chicago
Cheng Zhang, University of Chicago
Xiaodan Gu, University of Southern Mississippi
Jeffrey A. Hubbell, University of Chicago
Bozhi Tian, University of Chicago
Sihong Wang, University of Chicago

Document Type

Article

Publication Date

8-10-2023

School

Polymer Science and Engineering

Abstract

The use of bioelectronic devices relies on direct contact with soft biotissues. For transistor-type bioelectronic devices, the semiconductors that need to have direct interfacing with biotissues for effective signal transduction do not adhere well with wet tissues, thereby limiting the stability and conformability at the interface. We report a bioadhesive polymer semiconductor through a double-network structure formed by a bioadhesive brush polymer and a redox-active semiconducting polymer. The resulting semiconducting film can form rapid and strong adhesion with wet tissue surfaces together with high charge-carrier mobility of ~1 square centimeter per volt per second, high stretchability, and good biocompatibility. Further fabrication of a fully bioadhesive transistor sensor enabled us to produce high-quality and stable electrophysiological recordings on an isolated rat heart and in vivo rat muscles.

Publication Title

Science

Volume

381

Issue

6658

First Page

686

Last Page

693

Recommended Citation

Li, N., Li, Y., Cheng, Z., Liu, Y., Dai, Y., Kang, S., Li, S., Shan, N., Wai, S., Ziaja, A., Wang, Y., Strzalka, J., Liu, W., Zhang, C., Gu, X., Hubbell, J. A., Tian, B., Wang, S. (2023). Bioadhesive Polymer Semiconductors and Transistors For Intimate Biointerfaces. Science, 381(6658), 686-693.
Available at: https://aquila.usm.edu/fac_pubs/21676