Effect of Norovirus Inoculum Dose On Virus Kinetics, Shedding, and Symptoms
Document Type
Article
Publication Date
7-1-2023
Abstract
The effect of norovirus dose on outcomes such as virus shedding and symptoms after initial infection is not well understood. We performed a secondary analysis of a human challenge study by using Bayesian mixed-effects models. As the dose increased from 4.8 to 4,800 reverse transcription PCR units, the total amount of shed virus in feces increased from 4.5 × 1011 to 3.4 × 1012 genomic equivalent copies; in vomit, virus increased from 6.4 × 105 to 3.0 × 107 genomic equivalent copies. Onset time of viral shedding in feces decreased from 1.4 to 0.8 days, and time of peak viral shedding decreased from 2.3 to 1.5 days. Time to symptom onset decreased from 1.5 to 0.8 days. One type of symptom score increased. An increase in norovirus dose was associated with more rapid shedding and symptom onset and possibly increased severity. However, the effect on virus load and shedding was inconclusive.
Publication Title
Emerging Infectious Diseases
Volume
29
Issue
7
First Page
1349
Last Page
1356
Recommended Citation
Ge, Y.,
Billings, W.,
Opekun, A.,
Estes, M.,
Graham, D.,
Leon, J.,
Koelle, K.,
Shen, Y.,
Atmar, R.,
Lopman, B.,
Handel, A.
(2023). Effect of Norovirus Inoculum Dose On Virus Kinetics, Shedding, and Symptoms. Emerging Infectious Diseases, 29(7), 1349-1356.
Available at: https://aquila.usm.edu/fac_pubs/21682