Examining the use of a continuous marker of metabolic syndrome severity for detecting resting autonomic dysfunction in a multiracial sample of young adults

Authors

Ta'Quoris Newsome, University of Mississippi Medical CenterFollow
Austin J. Graybeal, The University of Southern MississippiFollow
Ryan S. Aultman, The University of Southern MississippiFollow
Anabelle Vallecillo-Bustos, The University of Southern Mississippi
Caleb F. Brandner, The University of IowaFollow
Sydney H. Swafford, The University of Southern Mississippi
Abby T. Compton, The University of Southern Mississippi
Sarah Parnell, The University of Southern Mississippi
Rhett C. Schimpf, The University of Southern Mississippi
Tanner Thorsen, The University of Southern Mississippi
Megan E. Renna, The University of Southern MississippiFollow
Jon Stavres, The University of Southern MississippiFollow

Document Type

Article

Publication Date

3-3-2025

School

Kinesiology and Nutrition

Abstract

Aims: To determine if a continuous marker of metabolic syndrome (MetS) severity (MetS_index) could identify early-onset autonomic dysfunction in young adults at an elevated risk (ER) of MetS.

Methods: Blood biomarkers and anthropometrics were collected from 178 individuals. Cardiovagal baroreflex sensitivity (cBRS) and heart rate variability (HRV) were evaluated during 10-min of rest. Linear regressions examined the associations between the MetS­_index and cBRS, as well as select indices of HRV. These variables were also compared between individuals meeting the criteria for MetS (MetS group), individuals not meeting the criteria for MetS but having a positive MetS_index (ER), and healthy controls (Con) matched for sex, race, and ethnicity (n = 20 per group).

Results: All indices of cBRS (all p ≤ 0.007) and the standard deviation of normal-to-normal r-r intervals (SDNN; p = 0.001) were attenuated in the MetS group compared to the Con group. However, no differences were observed between the Con and ER groups (p ≥ 0.395). The MetS_index did demonstrate a significant, albeit small (R² ≤ 0.038, β≤ −0.168, p ≤ 0.028) association with all indices of cBRS and SDNN.

Conclusions: The MetS_index is associated with indices of cBRS and HRV, but is not currently able to detect early-onset autonomic dysfunction in young adults with an elevated risk of MetS.

Publication Title

Frontiers in Cardiovascular Medicine

Volume

12

Recommended Citation

Newsome, T., Graybeal, A. J., Aultman, R. S., Vallecillo-Bustos, A., Brandner, C. F., Swafford, S. H., Compton, A. T., Parnell, S., Schimpf, R. C., Thorsen, T., Renna, M. E., Stavres, J. (2025). Examining the use of a continuous marker of metabolic syndrome severity for detecting resting autonomic dysfunction in a multiracial sample of young adults. Frontiers in Cardiovascular Medicine, 12.
Available at: https://aquila.usm.edu/fac_pubs/21887