Pre-existing immunity to influenza aids ferrets in developing stronger and broader H3 vaccine-induced antibody responses
Document Type
Article
Publication Date
8-30-2024
School
Biological, Environmental, and Earth Sciences
Abstract
Influenza seasons occur annually, building immune history for individuals, but the influence of this history on subsequent influenza vaccine protection remains unclear. We extracted data from an animal trial to study its potential impact. The trial involved 80 ferrets, each receiving either one type of infection or a placebo before vaccination. We quantified the vaccine protection by evaluating hemagglutination inhibition (HAI) antibody titer responses. We tested whether hosts with different infection histories exhibited similar level of responses when receiving the same vaccine for all homologous and heterologous outcomes. We observed that different pre-existing immunities were generally beneficial to vaccine induced responses, but varied in magnitude. Without pre-immunity, post-vaccination HAI titers after the 1st dose of the vaccine were less likely to be above 1:40, and a booster shot was needed. Our study suggests that pre-existing immunity may strengthen and extend the homologous and heterologous vaccine responses.
Publication Title
Vaccine
Volume
42
Issue
21
Recommended Citation
Ge, Y.,
Lu, Y.,
Allen, J.,
Einav, T.,
Nkaleke, D.,
Bai, F.,
Handel, A.,
Ross, T.,
Shen, Y.
(2024). Pre-existing immunity to influenza aids ferrets in developing stronger and broader H3 vaccine-induced antibody responses. Vaccine, 42(21).
Available at: https://aquila.usm.edu/fac_pubs/22311