Grinding-Induced Polymorphism in the Aporphine Alkaloid Magnoflorine

Document Type

Article

Publication Date

11-1-1996

Department

Chemistry and Biochemistry

School

Mathematics and Natural Sciences

Abstract

The aporphine alkaloid magnoflorine iodide was isolated from the plant Thalictrum thalictroides. Comparison of its solid state IR spectrum with an authentic standard revealed a change in the spectrum of the standard which was dependent upon the amount of grinding used in preparing the halide pellet. Four possible causes of these IR spectral changes can be considered: ion exchange with the metal halide, absorption of atmospheric moisture, a chemical reaction on the surface of the KI, or a polymorphic transition. The most likely cause of the observed alterations in the IR spectrum is a change in crystalline structure caused either by grinding or by recrystallization. This is the first report of polymorphism in magnoflorine.

Publication Title

Phytochemistry

Volume

43

Issue

5

First Page

1129

Last Page

1133

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