Document Type
Article
Publication Date
8-25-2005
Department
Biological Sciences
School
Biological, Environmental, and Earth Sciences
Abstract
Background
Epidemiological studies have associated estrogen replacement therapy with a lower risk of developing Alzheimer's disease, but a higher risk of developing breast cancer and certain cardiovascular disorders. The neuroprotective effect of estrogen prompted us to determine potential therapeutic impact of soy-derived estrogenic compounds. Transgenic C. elegans, that express human beta amyloid (Aβ), were fed with soy derived isoflavones genistein, daidzein and glycitein (100 μg/ml) and then examined for Aβ-induced paralysis and the levels of reactive oxygen species.
Results
Among the three compounds tested, only glycitein alleviated Aβ expression-induced paralysis in the transgenic C. elegans. This activity of glycitein correlated with a reduced level of hydrogen peroxide in the transgenic C. elegans. In vitro scavenging effects of glycitein on three types of reactive oxygen species confirmed its antioxidant properties. Furthermore, the transgenic C. elegans fed with glycitein exhibited reduced formation of β amyloid.
Conclusion
These findings suggest that a specific soy isoflavone glycitein may suppress Aβ toxicity through combined antioxidative activity and inhibition of Aβ deposition, thus may have therapeutic potential for prevention of Aβ associated neurodegenerative disorders.
Publication Title
BMC Neuroscience
Volume
6
Issue
54
First Page
1
Last Page
9
Recommended Citation
Gutierrez-Zepeda, A.,
Santell, R.,
Wu, Z.,
Brown, M.,
Wu, Y.,
Khan, I.,
Link, C. D.,
Zhao, B.,
Luo, Y.
(2005). Soy Isoflavone Glycitein Protects Against Beta Amyloid-Induced Toxicity and Oxidative Stress in Transgenic Caenorhabditis elegans. BMC Neuroscience, 6(54), 1-9.
Available at: https://aquila.usm.edu/fac_pubs/8580
Comments
Published by BMC Neuroscience at 10.1186/1471-2202-6-54.