Document Type
Article
Publication Date
1-1-2012
Department
Chemistry and Biochemistry
School
Mathematics and Natural Sciences
Abstract
A series of copper complexes were synthesized from benzo[d][1,3]dioxole-5-carbaldehyde (piperonal) thiosemicarbazones (RHpTSC where R = H, CH3, C2H5 or C6H5 (Ph)). The complexes show interesting variations in geometry depending on the thiosemicarbazone; a dinuclear complex [Cu(HpTSC)Cl]2, a mononuclear complex [Cu(RHpTSC)2Cl2] (R = CH3 or C2H5) and another mononuclear complex [Cu(PhHpTSC)(PhpTSC)Cl] was generated. The complexes bind in a moderately strong fashion to DNA with binding constants on the order of 104 M− 1. They are also strong binders of human serum albumin with binding constants near 104 M− 1. The complexes show good in vitro cytotoxic profiles against two human colon cancer cell lines (HCT-116 and HT29) and two human breast cancer cell lines (MCF-7 and MDA-MB-231) with IC50 values in the low millimolar concentration range.
Publication Title
Inorganic Chemistry Communications
Volume
15
First Page
225
Last Page
229
Recommended Citation
Beckford, F. A.,
Thessing, J.,
Stott, A.,
Holder, A. A.,
Poluektov, O. G.,
Li, L.,
Seeram, N. P.
(2012). Anticancer Activity and Biophysical Reactivity of Copper Complexes of 2-(benzo[d][1,3]dioxol-5-ylmethylene)-N-Alkylhydrazinecarbothioamides. Inorganic Chemistry Communications, 15, 225-229.
Available at: https://aquila.usm.edu/fac_pubs/8865
Comments
© 2012. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/.