A Simple and Efficient Method to Prepare Thioesters in Aqueous Solutions
Document Type
Article
Publication Date
6-20-2005
Department
Chemistry and Biochemistry
School
Mathematics and Natural Sciences
Abstract
A simple method is described for the efficient synthesis of biologic,ally-active thioesters in aqueous solutions. The method utilizes imidazole as a catalyst and easily synthesized acyl or aminoacyl adenylates to synthesize a variety of thioesters, from small molecules to macromolecules. Yields in excess of 90% can be achieved in less than 10 min at room temperature. Specifically, functional derivatization of RNA with biotin via thioester linkage is demonstrated. (c) 2005 Elsevier Ltd. All rights reserved.
Publication Title
Tetrahedron Letters
Volume
46
Issue
25
First Page
4307
Last Page
4310
Recommended Citation
Coleman, T. M.,
Li, N.,
Huang, F.
(2005). A Simple and Efficient Method to Prepare Thioesters in Aqueous Solutions. Tetrahedron Letters, 46(25), 4307-4310.
Available at: https://aquila.usm.edu/fac_pubs/9074