Date of Award
Spring 5-2013
Degree Type
Honors College Thesis
Department
Chemistry and Biochemistry
First Advisor
Faqing Huang
Advisor Department
Chemistry and Biochemistry
Abstract
Cancer treatment has much room for improvement, as therapies today cannot differentiate well between what cells are part of a tumor and which are healthy. Our research involves targeting cancer cells by their overexpressed folic acid receptors, and delivering small interfering RNAs (siRNAs) to silence genes crucial to cell survival by the RNA interference gene knockdown pathway. By using Gaussia luciferase siRNA (siGLuc) as a model for cell delivery, we have been able to test our ability to deliver siRNA via a gold nanoparticle delivery system, also developed in our lab. We also synthesized ribonucleotide reductase siRNA (siRRM2), which will become our lab’s gene of focus in the future, as this siRNA has potential to kill cancer cells.
Copyright
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Recommended Citation
Grenn, John Caleb, "Targeted Delivery of Ribonucleotide Reductase siRNA in Cancer Cells via Gold Nanoplexes" (2013). Honors Theses. 144.
https://aquila.usm.edu/honors_theses/144