Date of Award

5-2013

Degree Type

Honors College Thesis

Department

Chemistry and Biochemistry

First Advisor

Faqing Huang, Ph.D.

Advisor Department

Chemistry and Biochemistry

Abstract

Cancer treatment has much room for improvement, as therapies today cannot differentiate well between what cells are part of a tumor and which are healthy. Our research involves targeting cancer cells by their overexpressed folic acid receptors, and delivering small interfering RNAs (siRNAs) to silence genes crucial to cell survival by the RNA interference gene knockdown pathway. By using Gaussia luciferase siRNA (siGLuc) as a model for cell delivery, we have been able to test our ability to deliver siRNA via a gold nanoparticle delivery system, also developed in our lab. We also synthesized ribonucleotide reductase siRNA (siRRM2), which will become our lab’s gene of focus in the future, as this siRNA has potential to kill cancer cells.

Included in

Life Sciences Commons

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