Date of Award
Spring 5-11-2012
Degree Type
Honors College Thesis
Department
Chemistry and Biochemistry
First Advisor
Douglas Masterson
Advisor Department
Chemistry and Biochemistry
Abstract
Inhibitors of glutathione reductase (GR) have been synthesized and studied in order to reverse an increasing trend in resistance to common malaria treatments. Analogues of glutathione (GSH) are being synthesized in order to increase resistance to proteolysis, thereby acting as an inhibitor of GR. Through the use of unnatural amino acids, solution-phase synthesis of GSH can be easily performed using modified cysteine (Cys) residues. A modified Cys residue, 2-α-methyl-β-cysteine, has been successfully synthesized, and coupling of this residue with the other required residues of GSH, glycine (Gly) and glutamic acid (Glu), has the potential to be successfully synthesized in good yields, thereby creating a stable GSH analogue.
Copyright
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Recommended Citation
Freeman, Nathan, "Synthesis of a Glutathione Analogue Using 2-α-Methyl-β-Cysteine" (2012). Honors Theses. 33.
https://aquila.usm.edu/honors_theses/33