This article presents a teaching approach known as Ignorance-Oriented Instruction (IOI), which views ignorance as both the driving force and the goal of learning. IOI aims to prepare students for an uncertain future by cultivating their ability to learn by delving into their ignorance and making predictions for the unknown. Key principles underlying the practice of IOI, a course designed based on IOI, and A COPE TRAP model for formulating questions are proposed. The experiences of applying IOI in various classes show that students responded to IOI favorably, although IOI makes the course more challenging than ordinary lecture-based instruction. IOI also presents a significant challenge to instructors because some students’ questions cannot be met without preparation in advance. Overall, IOI offers a promising approach to education that can help students learn how to learn, thereby enhancing their capacity to cope with the future challenges.

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